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The Prostate Program
Henry Jay Lee, MD, PhD

Manuscripts (Selected)

1. Rye, D.B., Saper, C.B., Lee, H.J., and Wainer, B.H. Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry and some extra-pyramidal connections of the mesopontine tegmentum. J. Comp. Neurol. 259: 483-528, 1987.

2. Hallanger, A. E., Levey, A. I., Lee, H.J., Rye, D. B., and Wainer, B. H., The origins of cholinergic and other subcortical afferents to the rostral thalamus in the rat. J. Comp. Neurol. 262: 105-124, 1987.

3. Rye, D. B., Lee, H.J., Saper, C. B., and Wainer, B. H., Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat. J. Comp. Neurol. 269: 315-341, 1988.

4. Lee, H.J., Rye, D.B., Hallanger, A.E., Levey, A.I., and Wainer, B.H. Cholinergic versus noncholinergic efferents from the mesopontine tegmentum to the extrapyramidal motor system nuclei. J. Comp. Neurol. 275:469-492, 1988.

5. Wainer, B.H., Lee, H.J., Roback, J.D., and Hammond, D.N. The use of reaggregating cell cultures and immortalized central nervous system cells to study cholinergic trophic mechanisms. In: “Novel Treatments and Models for Alzheimer's Disease.” E.M. Meyer and J. Simpkins eds., Plenum Press, New York. pp. 71-94, 1989.

6. Hammond, D.N., Lee, H.J., and Wainer, B.H. A membrane-associated factor influences central cholinergic neuron development. Ann. Neurol. 26:445-446, 1989.

7. Hammond, D.N., Lee, H.J., Tonsgard, J.H. and Wainer, B.H. Development and characterization of clonal cell lines derived from septal cholinergic neurons. Brain Res. 512: 190-200, 1990.

8. Lee, H.J., Hammond, D.N., and Wainer, B.H. Immortalized young adult cholinergic neurons from the medial septal region: Production and characterization. Dev. Brain Res. 52: 219-228, 1990.

9. Lee, H.J., Hammond, D.N, Large, T.H., Sim, J.A., Brown, D.H., Otten, U.H., and Wainer, B.H. Neuronal properties and trophic activities of immortalized hippocampal cells from embryonic and young adult mice. J. Neurosci. 10: 1779-1787, 1990.

10. Hammond, D.N., Lee, H.J., and Wainer, B.H. A hippocampal cell line expresses a membrane-associated cholinergic trophic activity not attributable to nerve growth factor. In “Alzheimer's and Parkinson's Diseases II: Basic and Therapeutic Strategies.” T. Nagatsu, A. Fisher, and M. Yoshida eds. Plenum Press, pp. 631-635, 1990.

11. Hallanger, A.E., Lee, H.J. Price, S.D., and Wainer, B.H. The ultrastructure of ChAT-immunoreactive synaptic terminals in specific relay nuclei of the rat thalamus. J. Comp. Neurol. 299: 482-492, 1990.

12. Wainer, B.H., Lee, H.J., Roback, J.D., and Hammond, D.N. In vitro cultures as a model of the basal forebrain. Adv. Exp. Med. Biol. 295: 415-437, 1991.

13. Lee, H.J., Elliot, G., Hammond, D.N., Lee, V.M.-Y., and Wainer, B.H. Constitutive expression of the mature array neurofilament proteins by a CNS neuronal cell line: implications for regulated expression and phosphorylation. Brain Res. 558: 197-208, 1991.

14. Wainer, B.H., Lee, H.J., Roback, J.D., and Hammond, D.N. In vitro cultures as a model of the basal forebrain. In “The Basal Forebrain: Anatomy to Function.” P.W. Kalivas and T.C. Napier eds. Plenum Press, New York, New York, 1991.

15. Blusztajn, J.K., Venturini, A. Lee, H.J., and Wainer, B.H. Acetylcholine synthesis and release is enhanced by dibutyryl cyclic AMP in a neuronal cell line derived from mouse septum. J. Neurosci. 12: 793-799, 1992.

16 Wainer, B.H., Hammond, D.N., Lee, H.J., Roback, J.D., Choi, H.K, Won, L. and Heller, A. Establishment of clonal cell lines for the study of neural function and dysfunction. In “Research and Perspectives in Neurosciences.” Y. Christen and J. Mervaillie eds. Springer-Verlag, 1992.

17. Roback, J.D., Diede, S.J. Downen, M. Lee, H.J., Large, T.H., Otten, U. and Wainer, B.H. Expression of neurotrophins and the low-affinity NGF receptor in sepal and hippocampal reaggregate cultures: local physiologic effects of NGF synthesized in the septal region. Brain Res Dev Brain Res. 70:123-33, 1992

18. Weichselbaum R.R., Hallahan D.E., Beckett M.A., Mauceri H.J., Lee H.J., Sukhatme V.P., and Kufe D.W. Gene therapy targeted by *radiation* preferentially radiosensitizes tumor cells. Cancer Research. 54:4266-9, 1994.

19. Blusztajn J.K., Venturini A., Lee H .J., and Wainer B.H. Cholinergic phenotype of septal cell lines. Advances in Behavioral Biology, Vol 40. Treatment of Dementias: A New Generation of Progress; Second Suncoast Workshop on the Neurobiology of Aging, Meyer, E.M., et al. (ed) Amelia Island, FL, USA. Plenum Press: New York, NY 463-469. 1992.

20. Mauceri, H.J., Hallahan, D.E., Lee, H.J., Beckett, M.A., Sukhatme, V.P., and Weichselbaum, R.R.. Tumor Size Does Not Limit Radiation-Inducible Gene Therapy in a Human Xenograft Model. Rad Onc Invest. 3:238-242, 1996.

21. Weichselbaum, R.R.., Hallahan, D.E., Lee, H.J., Beckett, M.A., Sukhatme, V.P., and Kufe, D.W.. Gene Therapy Targeted by Radiation Preferentially Radiosensitizes Tumor Cells. Cancer Res. 54:4266-9, 1994.

22. Wallner, K.E., Lee, H.J., and Dattoli, M. Low risk of incontinence following prostate brachytherapy in patients with a prior TURP. Int J Radiat Oncol Biol Phys. 37:565-9, 1997.

23. Lee, H.J., Strong, E.W., Zelefsky, M.J., Shah, J.P., Pfister, D.G., Raben, A., Kraus, D.H., and Harrison, L.B. Long-term regional control after radiation therapy and neck dissection for squamous cell carcinoma of the base of tongue. Int J Radiat Oncol Biol Phys. 38: 995-00, 1997.

24. Harrison, L.B., Lee, H.J., Kraus, D.H., Zelefsky, M.J., Strong, E.W., Pfister, D.G., Raben, A., Shah, J.P., White, C., Carper, E., and Portenoy, R. Long-term results of primary radiation therapy for squamous cancer of the base of tongue. Head Neck 20: 668-73, 1998.

25. Gelblum, D.Y., Lee, H., Bilsky, M., Pinola, C., Longford, S., and Wallner, K. Radiographic findings and morbidity in patients treated with stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 42:391-5, 1998

26. Lee, H.J., and Posner, J. Radiosurgery for metastases from malignant melanoma. Cancer J. Sci. Am. 4:80-83, 1998.

27. Hong, L., Hunt, M., Chui, C., Spirou, S., Forster, K., Lee, H., Yahalom, J., Kutcher, G.J., and McCormick, B. Intensity-modulated tangential beam irradiation of the intact breast. Int J Radiat Oncol Biol Phys. 15:1155-64, 1999.

28. Bilsky, M.H,. Lis, E., Raizer, J., Lee, H., and Boland, P. The diagnosis and treatment of metastatic spinal tumor. Oncologist. 4:459-69, 1999.

29. Zelefsky, M.J., McKee, A.B,. Lee, H., and Leibel, S.A. Efficacy of oral sildenafil in patients with erectile dysfunction after radiotherapy for carcinoma of the prostate. Urology, 53:775-8, 1999.

30. Zelefsky, M.J., McKee, A.B., Lee, H., Leibel, S.A. Efficacy of oral sildenafil in patients with erectile dysfunction after radiotherapy for carcinoma of the prostate. Urology. 53:775-8, 1999.

31. Zelefsky, M.J., Kelly, W.K., Scher, H.I., Lee, H., Smart, T., Metz, E., Schwartz, L., Fuks, Z., Leibel, S.A. Results of a phase II study using estramustine phosphate and vinblastine in combination with high-dose three-dimensional conformal radiotherapy for patients with locally advanced prostate cancer. J Clin Oncol. 18:1936-41, 2000.

32. Zelefsky, M.J., Fuks, Z., Happersett, L., Lee, H.J., Ling, C.C., Burman, C.M., Hunt, M., Wolfe, T., Venkatraman, E.S., Jackson, A., Skwarchuk, M., Leibel, S.A. Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer. Radiother Oncol. 55:241-9, 2000.

33. Sandhu, A.S., Zelefsky, M.J., Lee, H.J., Lombardi, D., Fuks, Z., Leibel, S.A. Long-term urinary toxicity after 3-dimensional conformal radiotherapy for prostate cancer in patients with prior history of transurethral resection. Int J Radiat Oncol Biol Phys. 48: 643-7, 2000.

34. Forster, K.M., Lee, H.J., Sheldon, J.M., Spirou, S.V., Burman, C., Chui, C., Endemann, B., Fuks, Z.Y., Harrison, L.B., Kutcher, G.J., Ling, C.C., Woode, R.R., Zelefsky, M.J., and Leibel, S.A. IsoInverse planning and intensity modulated radiotherapy for anaplastic thyroid carcinoma. Int J Radiat Oncol Biol Phys. in preparation.

35. Lee, H.J., Dicker, A.P., Schwartz, L, Zelefsky, M.J., Leibel, S.A., and Fuks, Z. The evaluation of prostate-specific antigen, bone scan, and CT scan in the determination of local and distant failure in patients treated with three-dimensional conformal radiation therapy for carcinoma off the prostate. in preparation.

36. Zelefsky, M.J., Fuks, Z., Hunt, M., Lee, H.J., Lombardi, D., Ling, C.C., Reuter, V.E., Venkatraman, E.S., and Leibel, S.A. The impact of dose escalation on local control and disease free survival in 1100 patients with localized prostate cancer treated by 3-dimenstional conformal radiotherapy. J. Urology. in press.

37. Padula, G.D.A., Zelefsky, M.J., Venkatraman, E.S., Lee, H.J., Leibel, S.A. Normalization of serum testosterone levels in patients treated with neoadjuvant hormonal therapy and three dimensional conformal radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys. submitted.

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